Glycoanalytics Center of Excellence
One Stop Shop for a Wide Range of Glycoanalysis Needs
Glycoanalysis Services provided by Procognia
Procognia specializes in Glycoanalysis with a highly skilled team of scientists with an over a decade of experience in analyzing hundreds of diverse, challenging glycoproteins (IgG and non-IgGs).
Procognia's Glycoanalysis Center of Excellence offers a broad range of solutions for various Glycoanalysis needs based on its proprietary lectin array based GlycoScopeTM platform as well as on traditional Glycoanalysis methods of HPLC supported by MALDI. The scientific team also provides interpretation and consultation to guide and improve the customer's development decision making and efficiency.
The Glycoanalysis Center of Excellence is a one stop shop for:
- Process development
- Media development
- Manufacturing in-process control
- Comparability studies
- Discovery and Research
HPLC/UPLC Glycoanalysis
The following HPLC/UPLC Glycoanalysis servicare avaes ilable
o N-Linked and O-Linked Glycans analysis:
* Full set of enzymatic cleavage , purification and labeling
* Normal phase HPLC
* WAX (Weak Anion Exchange ) HPLC
* Two dimensional HPLC (WAX and NP)- for complicated Glycoanalysis
* Data analysis
o NANA/NGNA Ratio determination
* Enzymatic removal of sialic acid
* Purification and labeling of samples and standards
* RP-UPLC/HPLC separations
* Data analysis
* Full validation package
The R&D team is also interested in collaborative development projects with academic institutions, private companies, and other qualified parties.
GlycoScopeTM
The GlycoScopeTM is an efficient and validated tool for:
- Accurate close quantitative monitoring of the glycosylation profile along the entire process development and In-Process Control.
- Identification of Glycan Structure Activity Related (SAR) glycoprotein profiles.
It is applied on intact glycoproteins (IgG and non-IgG) at low concentrations and volume.
The GlycoScopeTM provides rapid results (same day results) enabling almost on-line decision making during process development and in-process control
For additional information please contact :
Glycoanalysiscenter@procognia.com
